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ISSFAL Policy Statement 3 |
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Page 8 of 9
Table 3: Risk for CHD Death by Quintile of Estimated EPA+DHA Intake in US Cohort and Case Control Studies
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Q1
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Q2
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Q3
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Q4
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Q5
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P value (CI)
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| Dolecek
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Person-years of follow-up
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13724
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12569
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13136
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13146
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13136
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Fish Servings
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NR
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NR
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NR
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NR
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NR
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EPA+DHA (mg/d)
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0
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9
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46
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153
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664
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RR CHD Death
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1
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1.08
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0.92
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0.89
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0.61
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<0.05
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Hu, Bronner et al.,
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Person-years of follow-up
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255434
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270898
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263131
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259454
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258583
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Fish Servings
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<1/mo
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1-3/mo
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1/wk
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2-4/wk
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>4/wk
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EPA+DHA (mg/d)
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67
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100
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178
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311
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533
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RR CHD Death
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1
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0.93
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0.69
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0.54
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0.62
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<0.001
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Albert, Campos et al.
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Person-years of follow-up
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7715
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65223
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56083
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61936
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62820
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Fish Servings
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<1/mo
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1-3/mo
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1-<2/wk
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2-4/wk
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>4/wk
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EPA+DHA (mg/d)
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10
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10-90
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90-163
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163-246
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>246
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RR Sudden Cardiac Death
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1
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0.58
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0.34
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0.60
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0.43
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0.21
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Siscovick et al.
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Person-years of follow-up
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N/A
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N/A
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N/A
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N/A
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N/A
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Fish Servings
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NR
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NR
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NR
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NR
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NR
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EPA+DHA (mg/d)
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0
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32
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98
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185
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455
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OR Primary Cardiac Arrest
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1
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0.9
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0.7
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0.5
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0.4
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(0.2-0.7)
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Mozaffarian et al.
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Person-years of follow-up
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3324
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8156
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7442
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5683
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11593
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Fish Servings
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<1/mo
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1-3/mo
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1/wk
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2/wk
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>2/wk
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EPA+DHA (mg/d)
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0
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128
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267
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547
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919
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RR IHD Death
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1
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0.78
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0.77
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0.53
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0.47
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0.002
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Ascherio et al.
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Person-years of follow-up
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50449
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49902
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48613
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47722
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45343
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Fish Servings/wk
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0.7
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1.6
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2.2
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3.2
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5.9
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Median EPA+DHA (mg/d)
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70
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150
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240
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340
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580
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RR CHD Death
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1
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1.14
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0.95
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1.03
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1.03
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NS
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nb. Studies cited are to be found on the following page:
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Lipid Matters