Monday 28th June

THEME: FROM THE MEMBRANE TO THE NUCLEUS

Professor Philip Calder, Congress Chairman

Mr Stuart Reed, former Chairman and Managing Director, Seven Seas Limited

INTRODUCTION

Dr Norman Salem, ISSFAL President

Announcement of and presentation by the Alexander Leaf Distinguished Scientist Award winner 2004

Professor Jorn Dyerberg, Capio Diagnostik a.s., Charlottenlund, Denmark

Chairperson: Tony Watts

PLENARY 1: Lipid rafts in membrane trafficking & signaling

Dr Kai Simons, Max-Planck Institute of Molecular Cell Biology and Genetics, Dresden, Germany

PLENARY 2: Looking for lipid rafts

Dr Ken Jacobson, University of North Carolina, Chapel Hill, USA

PLENARY 3: Fatty acids and cell signaling

Professor Holm Holmsen, University of Bergen, Bergen, Norway

PLENARY 4: Inositol lipids in cell signaling

Dr Robin Irvine, University of Cambridge, Cambridge, UK

PLENARY 5: New insights into regulation of gene expression and human health through LXR

Dr David Mangelsdorf, Howard Hughes Medical Institute, Dallas, USA

PLENARY 6: PPARs as fatty acid sensitive regulators of cellular functions

Professor Walter Wahli, University of Lausanne, Lausanne, Switzerland

CONCURRENT SESSIONS A-D

CONCURRENT SESSION A - Membrane structure and function

Chairpersons: Peter Quinn and Jan Glatz

What's so special about cholesterol?

Professor Ole Mouritsen, University of Southern Denmark, Odense, Denmark

A1 VISCOELASTIC PROPERTIES AND BIOLOGICAL FUNCTION OF POLYUNSATURATED LIPIDS

Horia I. Petrache1, Kannan Rajamoorthi2, Thomas J. McIntosh4, and Michael F. Brown2,3 1Laboratory of Physical and Structural Biology, NICHD, National Institutes of Health, Bethesda, MD, USA, Departments of 2Chemistry and 3Physics, University of Arizona, Tucson, AZ, USA, and 4Department of Cell Biology, Duke University School of Medicine, Durham, NC, USA

A2 MANIPULATION OF CHOLESTEROL AND SPHINGOMYELIN CONTENT IN BOVINE SYNAPTOSOMES ALTERS BENZODIAZEPINE BINDING TO THE GABA(A) RECEPTOR

Brian W. Bailey, Ph.D., Jennifer Lewis, Drake C. Mitchell, Ph.D., Laboratory of Membrane Biochemistry and Biophysics, NIH/NIAAA, Bethesda, MD, USA

A3 NUCLEAR ENVELOPE ASSEMBLY IS PROMOTED BY PHOSPHOINOSITIDE SPECIFIC PLC WITH SELECTIVE RECRUITMENT OF PtdIns ENRICHED MEMBRANES

Richard Byrne1, Marie Garnier1, Grielof Koster2, Matilda Katan3, Anthony D. Postle2, Dominic L. Poccia4 and Banafshé Larijani1 1CRUK-LRI, UK. 2University of Southampton,UK. 3ICR,UK. 4Amherst College,USA & Universidade, Lusófona, Portugal

A4 RATE AND LEVEL OF G PROTEIN-RECEPTOR COUPLING VARIES WITH CHOLESTEROL CONTENT IN ROS DISK MEMBRANES

Drake C. Mitchell, Ph.D., Shui-Lin Niu, Ph.D., Burton J. Litman, Ph.D. Laboratory of Membrane Biochemistry and Biophysics, NIH/NIAAA, Bethesda, MD, USA

A5 MYSTERY OF FATTY ACID TRANSPORT

Elena E. Pohl and Anna M. Voltchenko, Neuroscience Research Centre, Humboldt-University, Berlin, Germany

A6 THE EFFECTS OF AGING ON THE FATTY ACID COMPOSITION OF VARIOUS LIPIDS FRACTIONS OF THE RAT HEART

Richard P. Bazinet, Ho-Joo Lee, Francesca Bosetti, Stanley I. Rapoport, National Institutes of Health, National Institute on Aging, Brain Physiology and Metabolism Section Bethesda, MD, USA

CONCURRENT SESSION B - Cardiovascular Disease

B1 HUMAN MYOCARDIAL OMEGA-3 FATTY ACID LEVELS: EFFECTS CORRELATION WITH ERYTHROCYTES AND EFFECTS OF SUPPLEMENTATION

Scott Sands and William Harris. Mid America Heart Institute at Saint Luke's Hospital, Kansas City, MO, and Department of Medicine, University of Missouri-Kansas City, Kansas City, MO, USA

B2 ASSOCIATION BETWEEN INTAKE OF VERY LONG-CHAIN N-3 FATTY ACIDS FROM FISH AND ATRIAL FIBRILLATION IN ELDERLY. THE ROTTERDAM STUDY

Ingeborg A Brouwer1,2, Jan Heeringa3, Johanna M Geleijnse2, Peter L Zock1,2, Jacqueline CM Witteman3, 1Wageningen Centre for Food Sciences, Wageningen, The Netherlands, 2Division of Human Nutrition, Wageningen University, Wageningen, The Netherlands, 3Department of Epidemiology and Biostatistics, Erasmus Medical Center, Rotterdam, The Netherlands

B3 EFFECTS OF N-3 FATTY ACIDS FROM FISH ON PREMATURE VENTRICULAR COMPLEXES AND HEART RATE IN PATIENTS

Anouk Geelen1, Ingeborg A. Brouwer1, Evert G. Schouten1, Arie C. Maan2, Martijn B. Katan1, Peter L. Zock1, 1Wageningen Centre for Food Sciences (WCFS) and Division of Human Nutrition, Wageningen University, Wageningen, The Netherlands 2Foundation for ECG analysis, Leiden University Medical Center, Leiden, The Netherlands

B4 INFLUENCE OF HERRING ON BIOMARKERS FOR CARDIOVASCULAR DISEASE

Helen Allenström, Anna-Maria Langkilde, Ingrid Undeland, Ann Sofie Sandberg, Dep. Of Chemistry and Bioscience, Food Science, Chalmers University of Technology, 402 29 Göteborg, Sweden

B5 THE OMEGA-3 INDEX: A NEW RISK FACTOR FOR SUDDEN CARDIAC DEATH?

William Harris1 and Clemens von Schacky2., 1Mid America Heart Institute of Saint Luke's Hospital and the University of Missouri-Kansas City, USA; 2Univeristy of Munich, Munich, Germany

B6 UPTAKE AND ACCUMULATION OF DIFFERENT SUBCLASSES OF TRIGLYCERIDE RICH LIPOPROTEINS BY MONOCYTE-DERIVED MACROPHAGES

Eliz Anil, Esther Nova, Anna Palmer, Parveen Yaqoob., Hugh Sinclair Unit of Human Nutrition, School of Food Biosciences, The University of Reading, UK

Update on the GISSI trial

D Roberto Marchioli, Consorzio Mario Negri Sud, Santa Maria Imbaro, Italy

CONCURRENT SESSION C - Cell Cycle, apoptosis and cancer

Cancer cachexia in animal models

Professor Mike Tisdale, Pharmaceutical Sciences Research Institute, Birmingham, UK

C1 LACK OF CORRELATION BETWEEN PLASMA AND PROSTATE ALPHA-LINOLENIC ACID LEVELS

Nadia M Attar-Bashi1, Duo Li2 and Andrew J Sinclair1, 1Food Science, RMIT University, Melbourne, Australia, 2Department of Food Science & Nutrition, Zhejiang University, Hangzhou, China

C2 ACUTE TAMOXIFEN TREATMENT IN RATS PROVOKES GLOBAL CHANGES IN LIVER LIPID METABOLISM

Christopher Lelliott1,5, Miguel Lopez1, Matthias Laudes1, Samuel Virtue1, Robert Semple1, Giles Yeo1, Kiera Curtis1, Asish Saha2, David Wiggins3, Stephen O'Rahilly1, Julian Griffin4, Geoffrey Gibbons3, Antonio Vidal-Puig1. Department of Clinical Biochemistry1, and Biochemistry4 Cambridge University UK, Boston University2, USA, Oxford University 3 UK, AstraZeneca R&D, Mölndal, Sweden5

C3 EFFECT OF DIETS WITH DIFFERING N-6 TO N-3 PUFA RATIOS ON CACHEXIA AND TUMOR GROWTH IN WALKER 256 TUMOR-BEARING RATS

Nathalia Pizatoa, Sandro Bonattoa, Ricardo K. Yamazakia, Julia Aikawaa, Claudia Nogataa, Rogéria C. Munda, Everson A. Nunesa, Maressa Piconcellia, Rui Curib, Philip C. Calderc and Luiz Claudio Fernandesa. aDepartment of Physiology, Biological Sciences Building, Federal University of Paraná. bDepartment of Physiology and Biophysics, Institute of Biomedical Sciences, University of São Paulo-Brazil. cDepartment of Human Nutrition, University of Southampton, UK

C4 CERAMIDE UPREGULATION IS NECESSARY FOR THE DEVELOPMENT OF APOPTOSISDEPENDENT MURINE PULMONARY EMPHYSEMA

Irina Petrache1, Terry R. Medler1, Lijie Zheng2, and Rubin M. Tuder2, 1Division of Pulmonary and Critical Care Medicine, Department of Medicine and 2Department of Pathology, Baltimore MD, USA

N-3 fatty acids, the cell cycle and apoptosis

Dr Robert Chapkin, Centre for Environmental & Rural Health, Texas A&M University, College Station, USA

CONCURRENT SESSION D - Eicosanoids

Chairpersons: Michel Lagarde and Bill Lands

Resolvins and docosatrienes: novel anti-inflammatory and pro-resolving mediators derived from Omega-3

Professor Charles Serhan, Harvard Medical School, Boston, USA

D1 14,15-DIHYDROXYEICOSATRIENOIC ACID (14,15-DHET) ACTIVATES PEROXISOME PROLIFERATOR ACTIVATED RECEPTORS (PPARs) IN TRANSFECTED COS-7 CELLS

Xiang Fang, Shanming Hu, Shawn D. Harmon, and Arthur A. Spector, Departments of Biochemistry and Internal Medicine, Carver College of Medicine, University of Iowa, USA

D2 MECHANISMS INVOLVED IN THE LYMPHOCYTE-INDUCED PROSTACYCLIN SYNTHESIS IN HUMAN UMBILICAL VEIN ENDOTHELIAL CELLS

Dominguez Z, Merhi-Soussi F, Macovschi O, Dubois M, Nemoz G, Lagarde M, Prigent AF., Cátedra de Patología General y Fisiopatología Escuela de Medicina Luis Razetti. IME., Universidad Central de Venezuela and INSERM U585, Physiopathologie des Lipides et Membranes, Bât. Louis Pasteur, INSA de Lyon, France

D3 DOCOSAHEXAENOIC ACID (DHA, 22:6 n-3) SUPPRESSES CYCLOOXYGENASE (COX)-2 EXPRESSION AND ERK1/2 ACTIVATION IN ENDOTHELIAL CELLS. A POSSIBLE ANTI-ANGIOGENIC ACTION BY OMEGA-3 FATTY ACIDS

Massaro, M.1,2 Scoditti, E.2, Carluccio, M.A.2, Storelli, C.1 and De Caterina, R.2,3, 1University of Lecce, Italy 2C.N.R. Institute of Clinical Physiology, Pisa and Lecce, 3"G. d'Annunzio" University, Chieti, Italy

D4 COMPARISON OF IN VIVO AND IN VITRO SUPPLEMENTATION WITH LINOLEIC ACID ON UTERINE PROSTAGLANDIN PRODUCTION IN LATE GESTATION EWES

Z Cheng, M. Elmes, SE Kirkup, DRE Abayasekara & DC Wathes Reproduction and Development Group, Royal Veterinary College, Hatfield, Herts, UK

D5 DIETARY N-3 AND N-6 PUFA: THE YING AND YANG OF INTESTINAL TUMORIGENESIS

Jay Whelan1 and Michael F. McEntee2; Departments of 1Nutrition and 2Pathology, University of Tennessee, Knoxville, TN, USA

D6 FISH OIL ALTERS THE RATIO OF LPS-STIMULATED LTB 4 TO PGE 2 PRODUCTION BY PBMCs IN PATIENTS WITH SEVERE VASCULAR DISEASE BUT NOT IN HEALTHY CONTROLS

J.J. Carrero1, J.Madden 2, J. Hadley 2, N.Dastur 2, N.T.Luu 3, G.Nash 3E.Rainger 3, C.Shearman 2, W.M.Howell 2, P.C.Calder 2, R.Grimble2, 1. Puleva Biotech S.A. Granada Spain ,2 School of Medicine, University of Southampton, UK, England, 3School of Medicine, University of Birmingham, Birmingham, UK

Poster session1