THURSDAY MAY 9TH

THEME: LIPIDS IN NEURAL DEVELOPMENT AND DISEASE

Co-Chairs: Tom Brenna, Cornell University, USA and Ricardo Uauy, University of Santiago, Chile

Plenary Lecture 3.1: Cholesterol and Hedgehog Signalling.

Philip Beachy, Johns Hopkins University, USA

Plenary Lecture 3.2: Lipid Synthesis is an Integral Part of PUFA Metabolism in the Neonate.
Stephen Cunnane, University of Toronto and Laval University, Canada

Congress Chair’s Lecture 3.3:
Arachidonate and Docosahexaenoate in Perinatal Neurovascular Development.
Michael Crawford, University of North London, UK

09:30 – 10:00 Exhibits and Scientific Posters

10:00 – 12 noon Three Concurrent Oral Sessions

SESSION E: LIPIDS AND APOPTOSIS

Chair: Hee-Yong Kim, National Institute on Alcohol and Alcoholism, National Institutes of Health

E-1: The Effects of Total and HDL Cholesterol on Atherosclerotic Plaques from Sudden Coronary Death Patients: The Role of Apoptosis in Plaque Instability.
Renu Virmani, Frank D. Kolodgie., Allen P. Burke, Andrew Farb, Armed Forces Institute of Pathology, USA

E-2: Apoptotic and Anti-Proliferative Effects of PUFA.
Laura Jenski, Marshall University, USA

E-3: Protective Effects of Polyunsaturated Lipids in Neuronal Apoptosis.
Hee-Yong Kim, Mohammed Akbar, NIH, USA

E-4: Roles of Sphingosine Kinases in Apoptosis and Cancer.
Hong Liu1, Sarah Spiegel1, Sheldon Milstien2, 1 Virginia Commonwealth University, 2LCMR/NIMH/NIH, USA

E-5: Docosahexaenoic Acid Prevents Phenylephrine-Induced Cardiac Hypertrophy Through Ras-Raf-MAP Kinase Pathway.
Rafat A. Siddiqui, Michelle Hunter, Gary P. Zaloga, and William Stillwell, Indiana Purdue University, USA

E-6: Conjugated Linoleic Acids (CLAs) Induce Apoptotic Gene Expression in Prostate Cancer Cells.
Julio Ochoa1, Barun Majumder2, Steven Heys2, Andrew Farquharson1, Andrew Schofield2 and Klaus Wahle1 1Rowett Research Institute, Scotland, 2Aberdeen University Medical School, Scotland

SESSION F: LIPIDS IN CARDIOVASCULAR DISEASE – 1

Co-Chairs: Kelley Fitzpatrick, Saskatchewan Nutraceutical Network, Canada, and Kathy Musa, University of Toronto, Canada

F-1: Rationale and Design of a Clinical Trial on N-3 Fatty Acids and Cardiac Arrhythmia (SOFA).
Ingeborg A Brouwer, Wageningen Centre for Food Sciences, Netherlands, E.G. Schouten, Zock PL, M.B. Katan, Wageningen University, A. J. Camm, St. George Hospital and Medical School, UK, D. Böcker, Westfalische Wilhelm Universitat, Germany, E.F.D Wever, Antonius Hospital, Nieuwegein, R.N.W Hauer, University Medical Center, The Netherlands, P. Otto-Terlouw, The Netherlands

F-2: N-3 Fatty Acids do not Affect Heart Rate Variability and Baroreflex Sensitivity in Healthy Middle-Aged Subjects.
Anouk Geelen1, Peter L. Zock1, Cees A. Swenne2, Ingeborg A. Brouwer1, Evert G. Schouten1, Martijn B. Katan1, 1Wageningen University, 2Leiden University Medical Center, The Netherlands

F-3: The Effect of Docosahexaenoic Acid Supplementation on the In Vivo Retroconversion to Eicosapentaenoic Acid and Serum Lipids in Postmenopausal Women Receiving and not Receiving Hormone Replacement Therapy.
K.D. Stark and B.J. Holub, University of Guelph, Canada,

F-4: Effect of EPA and DHA on Oxidative Stress and Inflammatory Markers in Treated-Hypertensive Type II Diabetics.
Trevor A Mori, Richard J Woodman, Valerie Burke, Ian B Puddey, Kevin D Croft and Lawrence J Beilin, University of Western Australia, Australia.

F-5: Perinatal N-6 and N-3 Polyunsaturated Fatty Acids Affect Weight, Blood Pressure and Plasma Insulin Levels Later in Life.
M. Korotkova, B. Gabrielsson, L.Å. Hanson, B. Strandvik, Göteborg University, Sweden

F-6: Effects of Dietary N-3 and N-6 PUFA Intake on Atheromatous Plaque Stability.
F. Thies1, J.M Garry2, P. Yaqoob2, K. Rerkasem3, A. Chulakadabba3, J. Williams3, C.P. Shearman3, P.J. Gallagher3, P.C. Calder2 and R.F. Grimble2, 1University of Aberdeen , 2 University of Southampton, 3 Southampton General Hospital, UK

SESSION G: PSYCHIATRIC DISORDERS

Chair: Mehar Manku, Laxdale Limited, UK

G-1: Metabolism of PUFA and their Oxidative Metabolites in Schizophrenia.
Jeff Yao, University of Pittsburgh, USA

G-2: Treatment of Schizophrenia with Eicosapentaenoic Acid.
Malcolm Peet, University of Sheffield, UK

G-3: Treatment of Depression with EPA.
Mehar Manku, David Horrobin, Laxdale Limited, UK

G-4: Treatment of Transgenic Mice and Humans with Huntington’s Disease with PUFA.
Krishna Vaddadi, Monash University, Australia

12 noon – 13:30 Exhibits and Scientific Posters

12 noon – 13:30 ISSFAL Annual General Meeting

Plenary Lecture 4.1: Essential Fatty Acid Requirements for the Perinatal Primate. Tom Brenna, Cornell University, USA

Plenary Lecture 4.2: PUFA and Infant Development. Maria Makrides, Women’s & Children’s Hospital, Australia

Plenary Lecture 4.3: Polyunsaturates and the Aging Brain. Marina Lynch, Trinity College, Ireland

15:00 – 15:30 Exhibits and Scientific Posters

15:30 – 17:30 Three Concurrent Oral Sessions

17:30 – 19:30 Exhibits and Scientific Posters

SESSION H: BIOCHEMISTRY OF LIPIDS

Chair: Margaret Craig-Schmidt, Auburn University, USA

H-1: Nuclear Magnetic Resonance Spectra of Natural Undiluted Lipids: DHA-Rich Phospholipid and Triacylglycerol from Fish, and CLA Enriched Adipose from Livestock.
C. Leigh Broadhurst1, Walter F. Schmidt1, Alva D. Mitchell2, Michael A. Crawford3, Yqun Wang3, Rong Li4, 1U.S. Department of Agriculture, 2Animal and Natural Resources Institute, USA 3University of North London, UK, 4University of Maryland, USA

H-2: Can Omega-3 Fatty Acids Improve Duodenal Calcium Uptake?
Marianne Haag, Olga Magada, Linde Böhmer, Nola Dippenaar, Marlena Kruger, University of Pretoria, Australia

H-3: Membrane Polyunsaturates and the Sodium Pump: Insights from Mammals, Birds and Amphibians.
A.J. Hulbert, Nigel Turner, University of Wollongong, Australia

H-4: The Role of Polyunsaturated Fatty Acids, Lipoxygenases and Cyclooxygenases in Adipocyte Differentiation.
Lise Madsen1, Rasmus K. Petersen 2 , Morten B. Sørensen2, Claus Jørgensen2, Rolf K. Berge1 and Karsten Kristiansen2. 1University of Bergen, Norway; 2University of Denmark, Denmark

H-5: Docosahexaenoic Acid Induces Cell Cycle Arrest via Hypophosphorylation of Human Retinoblastoma Protein in Jurkat Leukemic Cells.
Rafat Siddiqui, Jacki Wiesehan, Michelle Hunter, Kevin Harvey, Gary Zaloga and William Stillwell. Indiana University-Purdue University, USA

H-6: Alterations in Cardiac Long-Chain Fatty Acid Metabolism and the Plasmalemmal Fatty Acid Transporter FAT/CD36 in Obese Zucker Rats.
S.L.M. Coort1, J. Willems1, G.J. van der Vusse1, A. Bonen2, J.F.C. Glatz1 and J.J.F.P. Luiken1, 1Maastricht University, The Netherlands, 2University of Waterloo, Canada.

SESSION I: POLYUNSATURATES IN NEUROLOGICAL DISORDERS – 1

Chair: Tom Hamazaki, Toyama Medical and Pharmaceutical University, Japan

I-1: Neuroprotective Effect of Docosahexaenoic Acid in Diabetic Neuropathy.
A.Gerbi2, T.C. Coste1, A. Djemli-Shipkolye1, P. Vague1, G. Pieroni 2 , D. Raccah 1, 1 Laboratoire de Diabetologie, France, 2INSERM U476, France.

I-2: Reduction in ADHD-Related Symptoms in Dyslexic Children Following Supplementation with Highly Unsaturated Fatty Acids: A Randomised Controlled Trial.
Alexandra J Richardson1, Eva Cyhlarova1, Catherine M Calvin1, Claire J Higgins2, Basant K Puri2, 1Oxford University, UK, 2Hammersmith Hospital, UK

I-3: Essential Fatty Acid Supplementation in Children with Apraxia of Speech: Therapeutic Outcomes.
Robert Katz1, Lori Roth2, Marilyn C. Agin3, 1Omega-3 Research Institute, Inc., 2Speech Language Pathologist,
3New York City Early Intervention, USA

I-4: Effect of Lithium on Arachidonic Acid Cascade in Brain of Unanesthetized Rats: Role for N-6/N-3 Competition in Bipolar Disorder.
Stanley I. Rapoport, Francesca Bosetti, National Institute of Health, USA

I-5: Ethanol Consumption Alters Electroretinograms and Depletes Neural Tissues of Docosahexaenoic Acid in Rhesus Monkeys: Nutritional Consequences of a Low n-3 Fatty Acid Diet.
Robert J. Pawlosky, Norman Salem Jr. NIH, Beltsville Human Nutrition Research Center, USA

I-6: Anticonvulsant Efficiency, Behavioral Performance and Cortisol Levels: A Comparison of Arbamazepine (CMP) and a Fatty Acid Compound (SR-3).
Shlomo Yehuda1, Sharon Rabinovitz1, David I. Mostofsky2, 1Bar Ilan University, Israel, 2Boston University, USA

SESSION J: POLYUNSATURATES, LIPID PEROXIDES AND ANTIOXIDANTS

Chair: Michel Lagarde, INSA/INSERM, France

J-1: Lipid Peroxidation and Platelet Function. Down Regulation by Long Chain n-3 Fatty Acids.
Michel Lagarde, Catherine Calzada, Michel Guichardant, Evelyne Véricel, INSERM U352, France

J-2: Lignan Profile in Indian Sesame Varieties and their Antioxidant Properties.
Dr. Ghafoorunissa, National Institute of Nutrition, India

J-3: Antioxidant or Prooxidant Effect of Docosahexaenoic Acid in Human Blood Platelets.
Evelyne Véricel, Anne Polette, Sandrine Bacot, Catherine Calzada, Michel Lagarde, INSERM U.352, France.

J-4: Dose-Dependent Effects of Fish Oil on LDL and HDL Oxidative Susceptibility and Functional Properties.
Rosemary C. Wander, Chung-Ting Han, Ye-Sun Lee, Michael D. Caputa., The University of North Carolina at Greensboro, USA

J-5: Antoxidant and Prooxidant Properties of Docosahexaenoic Acid.
Ephraim Yavin and Annette Brand, Weizmann Institute of Science, Israel

J-6: Effect of Dietary Oils with Different Degrees of Unsaturation on Peroxidative Injury and Aging in Rodents.
Harumi Okuyama, Nagoya City University, Japan

17:30 – 19:30 Exhibits and Scientific Posters