Tuesday 29th June
THEME: METABOLISM
Chairpersons: Art Spector and Gordon Bell
PLENARY 7: Structure/function relationships in fatty acid synthase
Dr Subrahmanyam Chirala, Baylor College of Medicine, Houston, USA
PLENARY 8: Regulation of desaturase expression and activity
Professor James Ntambi, University of Wisconsin-Madison, Madison, USA
Chairpersons: Klaus Wahle and Tom Brenna
Regulation of fatty acid and lipid synthesis
Dr Charles Rock, St Jude Children's Research Hospital, Memphis, USA
E1 SUCKLING RATS ACTIVELY RECYCLE CARBON FROM a-LINOLENATE (ALA) INTO NEWLY SYNTHESIZED LIPIDS DURING DEFICIENCY OF ?3 POLYUNSATURATES (PUFA)
S.C. Cunnane, M.A. Ryan, Y.H. Lin1, S-Y. Lim1 and N. Salem Jr1., Department of Nutritional Sciences, University of Toronto, Toronto, Canada, and 1Laboratory of Membrane Biochemistry and Biophysics, NIAAA, NIH, Rockville, MD, USA
E2 LINOLENIC ACID DOES NOT CONTRIBUTE APPRECIABLY TO THE BRAIN SYNTHESIS OF DOCOSAHEXAENOIC ACID IN THE ADULT RAT.
James C. DeMar, Kiazong Ma, Lisa Chang, Jane Bell, and Stanley I. Rapoport. Brain Physiology and Metabolism Section, National Institute on Aging, National Institutes of Health, Bethesda, MD, USA
E3 THE CONTROL OF SAPIENIC ACID BIOSYNTHESIS
Guillou H, D'Andrea S, Rioux V, Bouriel M, Catheline D, Legrand P, Laboratoire de Biochimie ENSAR-INRA, Agrocampus, Rennes cedex, FRANCE
E4 ELONGATION AND DESATURATION OF 18-CARBON NUTRIENTS DIFFER FROM 20-CARBON IN ADULT RATS AND HUMAN NEONATES
YH Lin, AR Llanos1, RJ Pawlosky, P Mena1, R Uauy1, N Salem, Jr., Laboratory of Membrane Biochemistry & Biophysics, NIAAA, NIH, USA 1Clinical Nutrition, INTA Univ de Chile, Santiago, Chile
E5 SREBP-1c: A KEY REGULATOR OF DE NOVO LIPOGENESIS
E.Tarling, A.Salter1 & A.Bennett, School of Biomedical Sciences, Queen's Medical Centre & 1School of Biosciences, Sutton Bonnington Campus, University of Nottingham, UK
E6 ROLE FOR ELOVL3 AND FATTY ACID CHAIN LENGTH IN VIVO
Rolf Westerberg, Jan-Erik Månsson, Lars Norlén, Andreas Jakobsson, Walter H. Holleran, Rune Toftgård, Mario R. Capecchi and Anders Jacobsson, The Wenner-Gren Institute, The Arrhenius Laboratories F3, Stockholm University, Sweden
CONCURRENT SESSION F - Cell signaling, transcription factors and gene expression
Chairpersons: Helen Roche and Eric Murphy
F1 DOCOSAHEXAENOIC ACID: A POSITIVE MODULATOR OF AKT-SIGNALING IN NEURONAL SURVIVAL
Hee-Yong Kim, Mohammed Akbar, Frances Calderon and Zhiming Wen, Section of Mass Spectrometry, Laboratory of Membrane Biochemistry and Biophysics, National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, Bethesda, MD, USA
F2 REPLACEMENT OF DHA BY DPA IN N-3 FATTY ACID DEFICIENCY DOWN REGULATES G PROTEIN-COUPLED SIGNALING IN RAT RETINAL ROD OUTER SEGMENTS
Shui-Lin Niu, Drake C. Mitchell, Sun-Young Lim, Zhi-Ming Wen, Hee-Yong Kim, Norman Salem, Jr., and Burton J. Litman Laboratory of Membrane Biochemistry & Biophysics, NIAAA, National Institutes of Health, Rockville, Maryland, USA
F3 INHIBITION OF PHENYLEPHRINE-INDUCED CARDIAC HYPERTROPHY BY DOCOSAHEXAENOIC ACID
Rafat A. Siddiqui1,2,3, Saame Raza Shaikh3, Richard Kovacs2, William Stillwell3, and Gary Zaloga1,2. 1Cellular Biochemistry Laboratory, Methodist Research Institute; 2Department of Medicine, and 3Department of Biology, Indiana University, Indianapolis, IN, USA
F4 TETRADECYLTHIOACETIC ACID (TTA) INDUCES LIGAND DEPENDENT COACTIVATION OF PPARs BY SRC COACTIVATORS AND PGC-1
Røst, TH.1, Mellgren, G.2, Berge RK.1, From the 1Lipid Research Group and 2Hormone Laboratory, Institute of Medicine, University of Bergen
F5 FATTY ACID DERIVATIVES AS PPAR-LIGANDS.
Laila N. Larsen, Linda Granlund*, Anne Kristin Holmeide**, Hilde I. Nebb*, Jan I. Pedersen*, Jon Bremer, Department of Biochemistry, *Department of Nutrition, **Department of Chemistry, University of Oslo, Norway
F6 THE EFFECT OF N-3 PUFA-ENRICHED OXIDISED-LDL ON THE EXPRESSION OF CARDIOVASCULAR-RELATED GENES IN A MONOCYTIC CELL LINE
Ian C. Kavanagh1, Carole E. Symes1, David S. Leake2 and Parveen Yaqoob1, 1Hugh Sinclair Unit of Human Nutrition, School of Food Biosciences, 2Animal and Microbial Sciences, The University of Reading, UK
Mechanisms of regulation of gene expression by fatty acids
Professor Manabu Nakamura, University of Illinois at Urbana-Champaign, Illinois, USA
CONCURRENT SESSION G - Maternal and Infant nutrition
Chairpersons: Stewart Forsyth and Bob Gibson
N-3 PUFA in infant nutrition and immune outcomes
Professor Catherine Field, University of Alberta, Edmonton, Canada
G1 DIFFERENT N-6 POLYUNSATURATED FATTY ACID COMPOSITION OF MILK FROM ALLERGIC AND NON-ALLERGIC MOTHERS
C. Beermann, A. Möller, J. Jelinek, G. Boehm, Numico Research, Friedrichsdorf, Germany
G2 PERINATAL DHA STATUS, EARLY FEEDING PRACTICE, AND PROBLEM BEHAVIOUR OF 7-YEAR-OLD CHILDREN
L. Krabbendam (1), E. Bakker (2), G. Hornstra (2), J. van Os (1), Departments of Psychiatry and Neuropsychology (1) and Human Biology (2), Maastricht University, The Netherlands
G3 ALTERATIONS IN THE FATTY ACID COMPOSITIONS OF VARIOUS TISSUES AFTER DIETARY SUPPLEMENTATION WITH DPAn-6 OR DHA
N. Salem, Jr., S-Y Lim, J. Loewke, K.D. Stark, Laboratory of Membrane Biochemistry & Biophysics, NIAAA, NIH, Rockville, MD, USA
G4 FISH OIL SUPPLEMENTATION OF LACTATING MOTHERS AFFECTS CYTOKINE PRODUCTION IN 21/2-YEAR-OLD CHILDREN
L.Lauritzen1, T.Kjær2, H.Frøkiær2, and K.F.Michaelsen1, 1Dept. Human Nutr., The Royal Vet. & Agricult. Univ., Frederiksberg, and 2BioCentrum, The Techn.Univ., Lyngby, Denmark
G5 FA PROFILES IN A BLOOD DROP COLLECTED IN A POPULATION OF 3-DAY-OLD BABIES : COMPARISONS WITH ADULT S AND CORRELATIONS WITH PHYSIOLOGIC, METABOLIC AND LIFE STYLE PARAMETERS
C. Galli1, C. Agostoni2, L. Colombo2 , C. Colombo1and F. Marangoni1, 1. Department of Pharmacological Sciences, University of Milan, Italy, 2. Department of Paediatrics, S. Paolo Hospital, Milan, Italy
G6 ALPHA-LINOLENIC ACID CONVERSION TO DOCOSA-HEXAENOIC ACID IN RATS IS REGULATED BY THE POLYUNSATURATED FAT CONTENT OF THE DIET
Robert A Gibson 1, Mark A Neumann 1, Eric L Lien 2, 1 Child Health Research Institute, Flinders Medical Centre, Adelaide, Australia, 2 Wyeth Nutrition, Philadelphia, Pennsylvania USA
Joint British Dietetic Association Forum
"Omega-3 Fatty Acids and Human Health: Perspectives for the 21st Century" - workshop
13:00 REGISTRATION
Co-Chairpersons:Dr Bill Lands, USA, Dr Angela Madden, London Metropolitan University, UK
14:00-14:30 OMEGA-3 FATTY ACIDS AND HUMAN HEALTH: SETTING THE SCENE
Professor Andrew Sinclair, RMIT University, Melbourne, Australia
14:30-15:00 THE IMPORTANCE OF OMEGA-3 FATTY ACIDS IN MATERNAL AND CHILD HEALTH
Ms Judy More, Freelance Dietitian, London, UK
15:00-15:30 OMEGA-3 FATTY ACIDS AND CARDIOVASCULAR DISEASE
Ms Lee Hooper, University Dental Hospital of Manchester, UK
15:50-16:20 OMEGA-3 FATTY ACIDS AND PSYCHIATRIC DISORDERS
Dr Iain Glen, The Ness Foundation, Scotland, UK
16:20-16:30 INTERACTIVE SOFTWARE FOR INDIVIDUALISED FOOD CHOICES
Dr Bill Lands, USA
16:30-17:00 Chaired Panel Discussion and questions from the floor
17:00 Close
Introductory Remarks: Dr Colin Barrow, Ocean Nutrition Canada
14:05-14:25 PCBS AND HEAVY METALS IN OMEGA-3 OIL DERIVED FROM FISH OIL: LEVELS AND METHODS OF MEASUREMENT
Dr Roger Clemens, USC School of Pharmacy, USA
14:25-14:45 MEASURING LIPID OXIDATION AND OTHER OIL QUALITY FACTORS BY FTIR SPECTROSCOPY
Dr Fred Van de Voort, McGill IR Group, Dept Food Science, McGill University. CANADA
14:45-15:05 DETERMINATION OF TRANS FATS IN FISH OIL PRODUCTS AND ITS IMPLICATIONS
Dr Jonathan Curtis, Ocean Nutrition Canada
15:05-15:35 HISTORY AND DEVELOPMENT OF THE COUNCIL FOR RESPONSIBLE NUTRITION OMEGA-3 MONOGRAPH
Mr Bjorn Rene, Head Technical Committee, CRN Omega3 Working Group, NORWAY
16:00-16:20 DEVELOPMENT OF USP MONOGRAPHS OF FISH OIL RICH IN OMEGA-3 FATTY ACIDS
Mr Lawrence Evans, Senior Scientific Associate, Information and Standards Development, USP, USA
16:20-16:40 TECHNOLOGICAL CHALLENGES IN APPLYING FISH OIL IN FUNCTIONAL FOODS
Dr Charlotte Jacobsen, Danish Institute for Fisheries Research, Department of Seafood Research, DENMARK
16:40-17:30 Round Table Discussion
17:30 Workshop close
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