Wednesday 30th June
THEME: GROWTH, DEVELOPMENT & CHRONIC DISEASE
Chairpersons: Michael Crawford and Norman Salem
PLENARY 9:
Fish and omega-3 fatty acid intake and pregnancy outcomes
Professor Sjurdur Olsen
Danish Epidemiology Science Centre, Copenhagen, Denmark
PLENARY 10:
DHA and retinal function
Professor Robert Anderson,The University of Oklahoma Health Sciences Centre, Oklahoma City, USA
Chairpersons: Ricardo Uuay and Maria Makrides
LCPUFA and children's cognitive development
Dr Peter Willatts,
University of Dundee, Dundee, UK
H1
N-6 PUFAs IN VIVO AND IN VITRO ON CYCLOOXYGENASE EXPRESSION AND PROSTAGLANDIN
SYNTHESIS BY FETO-PLACENTAL TISSUES OF THE PREGNANT EWE
SE Kirkup1, Z Cheng1, M. Elmes1, DC Wathes1, APF Flint2, EL Sheldrick2 K Derecka2 &
DRE Abayasekara1
1Reproduction and Development Group, Royal Veterinary College, Herts, UK
2Division of Animal Physiology, University of Nottingham, UK
H2
EICOSAPENTAENOIC ACID AND ARACHIDONIC ACID REGULATE PLACENTAL MATRIX
METALLOPROTEINASE AND HCG PRODUCTION IN OPPOSITE MANNERS
1K.A.R. Tobin, 2B. Halvorsen and 1A. K. Duttaroy*,1Dept of Nutrition, Faculty of Medicine, University of Oslo, 0316 Oslo, Norway and
2Research institute for Internal Medicine, Rikshospitalet University Hospital, Oslo, Norway
H3
EFFECTS OF INSULIN AND LEPTIN ON FATTY ACID UPTAKE UPTAKE BY HUMANTROPHOBLAST BeWO CELLS
A.K. Duttaroy*, A. Jørgensen and K.A.R Tobin,Dept of Nutrition, Faculty of Medicine, University of Oslo, Blindern, Norway
H4
PLACENTAL ARACHIDONATE & DOCOSAHEXAENOATE LEVELS ARE ENHANCED BY GESTATIONAL DIABETES
1Bitsanis D, 1Ghebremeskel K, 1Moodley T, 2Djahanbakhch OB, 1Crawford MA.,1IBCHN, London Metropolitan University; 2Department of Obstetrics and Gynaecology,
St. Bartholomew's Hospital and The Royal London School of Medicine, London, UK
H5
GESTATIONAL AGE AND BIRTHWEIGHT IN RELATION TO OMEGA-3 FATTY ACIDS AMONG INUIT (CANADA)
Michel Lucas1, Éric Dewailly1, Gina Muckle1, Pierre Ayotte1, Suzanne Bruneau1, Suzanne Gingras1,Marc Rhainds1 and Bruce J. Holub2.
11 Public Health Research Unit, Laval University Medical Research Centre (CHUQ), Ste-Foy (Québec) Canada; 22 Department of Human Biology and Nutritional Sciences, University of Guelph,
Guelph (Ontario) Canada
H6
MERCURY AND ESSENTIAL FATTY ACID INTERACTIONS: EFFECT ON NEONATAL RAT BRAIN AND LIVER PHOSPHOLIPID FATTY ACID COMPOSITION
M.C. Craig-Schmidt, M.C. Newland, I.A. Sachitano, and C. Teodorescu. Auburn University, USA
CONCURRENT SESSION I - Inflammation and inflammatory disorders
Chairpersons: Philip Calder and Stephen Cunnane
I1
EFFECTS OF FISH OIL SUPPLEMENTATION ON ABILITY OF MONOCYTES TO INVOKE A PROINFLAMMATORY
RESPONSE IN ENDOTHELIAL CELLS
N.T.Luu 2, J.Madden1, J. Hadley 1, N.Dastur 1, C.Shearman 1, W.M.Howell 1, P.Calder 1, R.Grimble 1,
G.E.Rainger 2, G.Nash 2
1 School of Medicine, University of Southampton, Southampton, England, 2School of Medicine,
University of Birmingham, UK
I2
THE EFFECTS OF CONSUMPTION OF A FISH AND BORAGE SEED OIL SUPPLEMENT ON SERUM LIPIDS AND SELECTED CYTOKINES IN RHEUMATOID ARTHRITIS PATIENTS
Maggie Laidlaw and Dr. Bruce Holub, Department of Human Biology and Nutritional Sciences
University of Guelph, Guelph, Ontario, Canada
I3
REDUCED JOINT PAIN AFTER SHORT-TERM DUODENAL ADMINISTRATION OF SEAL OIL IN PATIENTS WITH INFLAMMATORY BOWEL DISEASE: COMPARISON WITH SOY OIL
Tormod Bjørkkjær1, Linn Anne Brunborg1, Gülen Arslan1.2, Ragna Anne Lind2, Johan G. Brun3,Merete Valen3, Beate Klementsen1, Arnold Berstad2 & Livar Frøyland1
1National Institute of Nutrition and Seafood Research (NIFES), Bergen, Norway, 2Division of Gastro-enterology and 3Division of Rheumatology, Institute of Medicine, Haukeland University Hospital
(HUH), Bergen, Norway
I4
A RANDOMISED CONTROLLED TRIAL OF FISH OIL PLUS ANTIOXIDANTS ON BONE TURNOVER IN CROHN'S DISEASE
TM Trebble, NK Arden, MA Stroud, DR Fine, SA Wootton, MA Mullee, PC Calder, Institute of Human Nutrition, University of Southampton, UK
I5
LOW GRADE INFLAMMATORY STRESS AND POLYMORPHISMS IN IL-6 AND TNF-a GENES MODULATE THE EFFECTS OF FISH OIL SUPPLEMENTATION ON TNF-a PRODUCTION BY
PBMCs IN HEALTHY MEN
O.Markovic, G.O'Reilly, H.Fussell, S. Turner, P.C.Calder, W.M.Howell, R.F.Grimble, School of Medicine, University of Southampton, UK
I6
C20-POLYUNSATURATED FATTY ACIDS MODIFY MAST CELL EFFECTORS RELEVANT TO CANINE ATOPIC DERMATITIS
Herbert Fuhrmann, Thomas Gück, Institute of Biochemistry, Faculty of Veterinary Medicine
University of Leipzig, Germany
Dietary ALA may have unique protective effects on inflammatory disorders in the skin;
atopic dermatitis and UV-induced tumourigenesis
Professor Harumi Okuyama, Nagoya City University, Nagoya, Japan
CONCURRENT SESSION J - Conjugated linoleic acid
Chairpersons: Klaus Wahle and Parveen Yaqoob
J1
EFFECTS OF FATTY ACIDS ON SKELETAL MUSCLE CELL DIFFERENTIATION IN VITRO
Brameld, JM, Hurley, MS, Anderson, KA, Flux, C and Salter, AM
Division of Nutritional Biochemistry, School of Biosciences, University of Nottingham, UK
J2
MODIFICATION OF MOUSE LIVER LIPID METABOLISM BY PURIFIED ISOMERS OF CONJUGATED
LINOLEIC ACID (CLA)
DS Kelley1, GL Bartolini1, JM Warren1, VA Simon1, BE Mackey2, and KL Erickson3. 1Western Human
Nutrition Research Center, ARS, USDA, and Dept of Nutrition, and 3Dept of Cell Biology, UCD,
Davis, CA, and 2Western Regional Research Center, Albany, CA, USA
J3
EFFECT OF A VACCENIC ACID (VA)/CONJUGATED LINOLEIC ACID (CLA)-ENRICHED BUTTER ON PLASMA LIPOPROTEINS IN THE CHOLESTEROL-FED HAMSTER
Horne, C.A.M., Lock, A.*, Hurley, M., Bauman, D.E.*, and Salter, A. Division of Nutritional Biochemistry, School of Biosciences, University of Nottingham, UK
and *Department of Animal Science, Cornell University, Ithaca, USA
J4
OPPOSING EFFECTS OF CIS-9,TRANS-11 AND TRANS-10,CIS-12 CONJUGATED LINOLEIC ACID ON BLOOD LIPIDS IN HEALTHY HUMANS
Sabine Tricon1, Graham C Burdge2, Samantha Kew1, Tapati Banerjee2, Jennifer J Russell2, Emma L Jones1, Robert F Grimble2, Christine M Williams1, Parveen Yaqoob1 and Philip C Calder2 ,
1 University of Reading, UK. 2 University of Southampton, UK
J5
EFFECTS OF TRANS-10, CIS-12 (T10,C12) AND CIS-9, TRANS-11 (C9,T11) CLA ON THE PLASMA FATTY ACID PROFILE AND EXPRESSION OF DESATURASES IN HUMANS
Myriam A.M.A. Thijssen1, Jean-Louis Sébédio2, Asgeir Saebo3, Taous S. Lassel4, and Ronald P. Mensink1.
1Maastricht University, Maastricht, The Netherlands; 2INRA, Dijon, France; 3Natural Lipids Ltd, Hovdebygda, Norway; 4Danone-Vitapole Palaiseau, France
J6
EFFECTS OF CONJUGATED LINOLEIC ACID ON LINOLEIC AND LINOLENIC ACID METABOLISM IN HUMANS
Anu M. Turpeinen1, Riitta Freese1, Sonja Bärlund1, Peter Lawrence2, J. Thomas Brenna2, 1Dept. of Applied Chemistry and Microbiology (Nutrition), University of Helsinki, Finland;
2Division of Nutritional Sciences, Cornell University, Ithaca, NY, USA
CLAs as precursors of a new family of PUFAs
Dr Sebastiano Banni,University of Cagliari, Cagliari, Italy
CONCURRENT SESSION K - Lipoproteins, lipaemia and lipoprotein metabolism
Chairpersons: Christine Williams and Bill Harris
Plant sterols and stanols
Professor Ronald Mensink,
University of Maastricht, Maastricht, The Netherlands
K1
HEPATIC PRODUCTION RATE OF VERY-LOW-DENSITY LIPOPROTEIN TRIACYLGLYCEROL
(VLDL-TG) PRODUCTION RATE BETWEEN FASTED AND FED STATES IN HEALTHY MEN
Brian R. Barrows, Elizabeth J. Parks, Department of Food Science and Nutrition, University of Minnesota, Twin Cities, MN, USA
K2
MEAL FATTY ACIDS INFLUENCE THE LIPID, APO C-III and APO E CONTENT OF TAG-RICH LIPOPROTEINS IN THE SF>400 AND SF 60-400 FRACTIONS OF PLASMA
Kim G Jackson, Emma J Wolstencroft, Paul A Bateman, Parveen Yaqoob and Christine M Williams. Hugh Sinclair Unit of Human Nutrition, School of Food Biosciences, The University of Reading, UK
K3
IMPACT OF MEAL FATTY ACIDS ON CHYLOMICRON SECRETION, COMPOSITION AND PARTICLE SIZE: IN VITRO AND IN VIVO COMPARISON
Vatsala Maitin, Paul A Bateman, Kim Jackson, Parveen Yaqoob and Christine M Williams.Hugh Sinclair Unit of Human Nutrition, School of Food Biosciences, The University of Reading, UK
K4
THE IMPACT OF EATING SALMON FILLETS WITH DIFFERENT AMOUNTS OF n-3 PUFA'S ONSERUM FATTY ACIDS AND LIPID LEVELS IN PATIENTS WITH CORONARY HEART DISEASE
1National Institute of Nutrition and Seafood Research (NIFES), Bergen, Norway, 2School ofL. Froyland1, SL Seierstad2, I. Seljeflot3, O. Johansen3, R. Hansen3, H. Meltzer4, G. Rosenlund5 and H. Arnesen3 Veterinary Medicine, Oslo, Norway, 3Ullevål University Hospital, Oslo, Norway, 4National Institute of
Public Health, Oslo, Norway, 5Nutreco ARC, Stavanger, Norway
K5
EFFECTS OF DOCOSAHEXAENOIC ACID RICH MICROALGAE OIL ON FATTY ACIDS, PLASMA LIPIDS AND VISUAL EVOKED POTENTIALS IN VEGETARIANS
Geppert J, Kraft V, Demmelmair H, Koletzko B, Division of Metabolism and Nutrition,
Dr. von Hauner Children's Hospital, Munich, Germany
K6
EFFECTS OF DIETARY FATTY ACIDS ON LIPOPROTEIN METABOLISM AND LIVER PROTEOME IN APOE*3-LEIDEN TRANSGENIC MICE
1Rowett Research Institute, Aberdeen, UK; 2TNO PG, Leiden, The Netherlands; 3TNO Nutrition &B de Roos1, I Duivenvoorden2, G Rucklidge1, M Reid1, K Pickard1, R-J Lamers3, PJ Voshol2,LM Havekes2, B Teusink2. Food Research, Zeist, The Netherlands
DAVID HORROBIN MEMORIAL LECTURE:
Dietary fatty acids and mental health
Dr Joe Hibbeln,NIAAA/NIA, Rockville, USA
Chairperson: Rudolph Riemersma
PLENARY 11:
Fatty acids, genes and cardiovascular risk
Professor Jose Ordovas, JM-USDA-HNRCA at Tufts University, Boston, USA
CONCURRENT SESSIONS L - N
CONCURRENT SESSION L
- Fatty acids and neurological, psychiatric and psychological disorders
Chairperson: Michael Crawford and Tomohito Hamazaki
LCPUFA and childhood psychiatric disorders
Dr Alex Richardson
University of Oxford, Oxford, UK
L1
MEMBRANE FATTY ACIDS, READING AND SPELLING IN DYSLEXIC AND NON-DYSLEXIC ADULTS
J.G.Bell,1 M.A.Ross,2 E.Cyhlarova,2 A.Shrier2 J.R.Dick1, R.J. Henderson1 and A.J.Richardson.2,1Institute of Aquaculture, Stirling University, 2University Lab. of Physiology, Oxford, UK
L2
RED CELL MEMBRANE OMEGA-3 FATTY ACIDS IN SOCIAL PHOBIA (SP) PATIENTS
Green P.1,3, Hermesh H.2, Monselise A.3, Weizman A.2, Marom S.2,1The Laboratory for the Study of Fatty Acids, the Felsenstein Center for Medical Research;
2Anxiety Disorders & Behavior Therapy Unit, Geha Mental Health Center; 3Department of Internal Medicine B, Rabin Medical Center, Beilinson Campus; and the Sackler School of Medicine,
Tel-Aviv University
L3
SUICIDE ATTEMPT AND N-3 FATTY ACID LEVELS IN RED BLOOD CELLS - A CASE CONTROL STUDY IN CHINA
Mingming Huan, 1 Kei Hamazaki, 1 Yueji Sun, 2 Miho Itomura, 1 Shiro Watanabe, 1and Tomohito Hamazaki 1
1 Toyama Medical and Pharmaceutical University, Japan, 2 Dalian Medical University, China
L4
EFFECTS OF ANDROGENS ON FATTY ACIDS METABOLISM AND MODIFIED EXPRESSION OF THE ANDROGEN METABOLIZING ENZYME 5ALPHA REDUCTASE IN THE NEURODEGENERATIVE
DISEASE X-LINKED ADRENOLEUKODYSTROPHY
A.Petroni*, M.Blasevich*, M.Cappa§, R.Beretta* and G.Uziel# *Departement of Pharmacological Sciences, University of Milan , via Balzaretti 9, 20133, Milan,
Italy;§ Department of Pediatrics and Adolescentology, Ospedale Pediatrico "Bambino Gesù",
Palidoro, Rome, Italy; #Istituto Neurologico "C.Besta", Milan, Italy
L5
THE RELATIONSHIP BETWEEN FOLATE AND DOCOSAHEXAENOIC ACID IN HUMANS
John Umhau, Karl Dauphinais, Daniel Nahrwold, Sunil Patel, Joseph Hibbeln, David George:From the National Institute on Alcohol Abuse and Alcoholism, Laboratory of Clinical Studies,
Bethesda, MD, USA
L6
OMEGA-3 AND OMEGA-6 POLYUNSATURATED FATTY ACIDS ENHANCE NEURITE OUTGROWTH IN RAT DORSAL ROOT GANGLIA CULTURES
Simon Dyall, Lesley Robson, David Sidloff and Adina Michael-Titus,Neuroscience Centre, Institute of Cell and Molecular Sciences, Barts and The London, Queen Mary's
School of Medicine and Dentistry, London, UK
CONCURRENT SESSION M - Obesity, insulin resistance and metabolic syndrome
Chairpersons: Tom Sanders and Ricardo Uauy
Reduction of adiposity by Omega-3 oils: targeting metabolism of fat cells
Dr Jan Kopecky, Institute of Physiology, Academy of Sciences of the Czech Republic,
Prague, Czech Republic
M1
ENHANCED SARCOLEMMA FAT/CD36 CONTENT AND TRIACYLGLYCEROL STORAGE IN CARDIAC MYOCYTES FROM OBESE ZUCKER RATS
Cardiovascular Research Institute Maastricht (CARIM), The Netherlands; *Human Biol & Nutr Sciences,S.L.M. Coort, D.P.Y. Koonen, J. Willems, W.A. Coumans, A. Chabowski*, A. Bonen*, J.J.F.P. Luiken, J.F.C. Glatz Guelph University, Canada
M2
EVALUATION OF SERUM LIPID LEVELS AND THEIR CORRELATION WITH HBA1C AS A METABOLIC CONTROL INDEX IN TYPE 1 DIABETIC CHILDREN AND ADOLESCENTS
Nobahar V., MD, Heidari A., MD, Vakili R., MD, Department of Pediatrics, Mashhad University of Medical Sciences, Mashhad, Iran
M3
RESISTIN EXPRESSION IN CULTURED ADIPOCYTES IS REDUCED BY ARACHIDONIC ACID
Fred Haugen, Naeem Zhaid, Knut T. Dalen, Kristin Hollung, Hilde I. Nebb and Christian A. Drevon, Department of Nutrition, Institute of Basic Medical Sciences, University of Oslo, Oslo, Norway
M4
N-3 FATTY ACIDS MODULATE TH1 AND TH2 DICHOTOMY IN GESTATIONAL DIABETIC RATS AND THEIR MACROSOMIC OFFSPRING
Naim Akhtar Khan and Aziz Hichami, UPRES Lipides & Nutrition, Université de Bourgogne, Dijon, France
M5
OBESITY IN CHILDREN IS INVERSELY RELATED TO THE CONCENTRATION OF W3 FATTY ACIDS IN SERUM PHOSPHOLIPIDS
Mårild S1, Karlsson M1, Lönn L2, Brandström J2, Friberg P3, Strandvik B1, Depts of Pediatrics1, Radiology2 and Clinical Physiology3, Sahlgrenska Academy, Göteborg University,
Göteborg, Sweden
M6
CONJUGATED LINOLEIC ACID SUPPLEMENTATION IN TYPE 2 DIABETES MELLITUS
F. Moloney1, A. Mullen1 , T.P. Yeow2, J.J. Nolan2 and H.M. Roche1, 1Nutrigenomics Research Group, Trinity Centre for Health Sciences, St. James's Hospital, Dublin,
Ireland, 2 Metabolic Research Unit , St. James's Hospital, Dublin, Ireland
Chairpersons: Parveen Yaqoob and Philip Calder
N1
DOCOSAHEXAENOIC ACID MODULATES CLASS I MAJOR HISTOCOMPATIBILITY COMPLEX
PROTEIN FUNCTION
Kaleb Hypes1, William Stillwell2, and Laura Jenski1,*1Department of Biological Sciences, Marshall University, Huntington, WV, USA; 2Department of Biology,
IUPUI, Indianapolis, USA
N2
MEMBRANE N-3 POLYUNSATURATED FATTY ACIDS MODULATE MATURATION OF MURINE DENDRITIC CELLS
Tanja MR Kjaer, MSc, PhD, Hanne R Christensen, MSc, PhD, Trine Porsgaard, MSc, PhD and
Biochemistry and Nutrition Group, BioCentrum-DTU, Technical University of Denmark, DK-2800 Lyngby, Hanne Frokiaer, MSc, PhD. Denmark
N3
THE FATTY ACID COMPOSITION OF DENDRITIC CELLS IS SITE-SPECIFIC, CHANGES WITH CHRONIC INFLAMMATION AND CORRELATES WITH THAT OF CONTIGUOUS ADIPOCYTES
Caroline M. Pond, Christine A. Mattacks & Dawn Sadler, Department of Biological Sciences, The Open University, Milton Keynes, UK
N4
OMEGA-3 FATTY ACIDS SUPPLEMENTATION ENHANCES IMMUNE RESPONSE IN SCHOOLCHILDREN: A RANDOMIZED DOUBLE-BLIND PLACEBO-CONTROLLED TRIAL
Alice Thienprasert1, Nattawat Onlamoon2, Kasama Sukapirom2, Kovit Pattanapanyasat2, Suched Samuhaseneetoo1
1Silpakorn University; 2Mahidol University; Thailand
N5
CONJUGATED LINOLEIC ACID SUPPLEMENTATION DECREASES EX VIVO HUMAN PBMC INTERLEUKIN 2 EXPRESSION AND SECRETION
A. Mullen, F. Moloney, A. Nugent, M.J. Gibney and H.M. Roche, Nutrigenomics, Institute of Molecular Medicine, Trinity Centre for Health Sciences, St. James's Hospital,
Dublin, Ireland
N6
ACUTE ELEVATION OF PLASMA FFA INDUCES IMPAIRMENT IN HUMAN T CELL FUNCTIONS
A. Larbi*, A. Grenier, F. Frisch, A.C. Carpentier, T. Fülöp, Department of Medicine, Université de Sherbrooke, QUE, Canada
PUFA and lipid rafts in T cells - relationship to T cell function
Professor Thomas Stulnig, University of Vienna, Vienna, Austria
Mini Symposium: Olive Oil & the Mediterranean Diet
Sponsored by:
Chairpersons: Christine Williams and Claudio Galli
The Mediterranean Diet and Cancer
Professor Antonia Trichopoulou
Athens, Greece
The Mediterranean Diet and Cardiovascular Epidemiology
Dr Miguel A Martinez-Gonzalez
University of Navarra, Pamplona, Spain
Mediterranean Diet: role of antioxidants
Dr Francesco Visioli, University of Milan, Milan, Italy
NUTRITIONAL AND HEALTH ASPECTS OF OLIVE OIL
(tocopherols, phenolic compounds, carotenoids, etc.), lend it very important properties in providing
Olive oil is the chief source of fat in the Mediterranean diet, which is attracting growing interest as a result of recent studies on disease prevention. The key to the biological potential, nutritional properties and
organoleptic characteristics of olive oil lies in its composition, which is also central to understanding its functions. Being a natural fruit juice, it retains the taste, aroma, vitamins and properties of the olive.
The monounsaturated fatty acids, mainly oleic acid (55-87%), in olive oil make it more resistant to heat and more stable. The minor components, particularly the large amount of antioxidants and vitamins protection against free radical-induced damage and preventing cancer formation and ageing.
A body of scientific evidence exists on the heart-healthy role of olive oil in the primary and secondary prevention of cardiovascular disease. It prevents arteriosclerosis and its related risks, high blood pressure,
acute myocardial infarction, heart and kidney failure and cerebrovascular accidents. An olive oil-rich diet lowers total cholesterol, LDL-cholesterol and triglycerides, and raises HDL-cholesterol. It has been
demonstrated to have an anti-thrombotic and anti-platelet-aggregating effect, and it has become one of the best options for preventing and controlling diabetes and obesity. Olive oil stimulates growth; it
encourages calcium absorption and bone mineralisation. It enhances the functioning of the immune, digestive and hepato-biliary systems and it has a protective, toning effect on the skin, preventing the
appearance of skin lesions and diminishing the signs of ageing. All this findings are of critical importance to the IOOC olive oil promotional activities which are aimed at
better informing targeted consumers with limited information and experience with the product.
Olive Oil and Modulation of Cell Signalling in Disease Prevention
Professor Klaus Wahle,The Robert Gordon University, Aberdeen, UK
NEW DATA-PROCESSING TECHNOLOGIES - DESIGNING A RELATIONAL DATABASE- FOR FATTY
ACIDS PROFILES IN MEDITERRANEAN PATIENTS WITH CARDIOVASCULAR DISEASES
El Mejaber W.1, Miguet J.1, Gutowski N.1, Gleize B.1, Payet M.1, Duran MJ.2 , Sennoune S.2 , Paganelli F.1, Pieroni G.1, Maixent JM.1 1 :Université de Poitiers & Marseille, France
2 :Texas Tech University., USA
Poster session 2
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